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The Proof with Simon Hill

The Proof with Simon Hill

The Science of Metabolic Flexibility, Zone 2, and Reversing Diabetes | A Masterclass

Jul 27, 2026 · 2h 20m

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About this episode

Metabolic dysfunction rarely announces itself. We tend to think of metabolic health as a line you cross the day you are diagnosed with type 2 diabetes, but the decay usually begins years earlier, at the level of the cell. In this masterclass I bring together Dr Iñigo San Millán, Dr Alan Flanagan, Dr Kevin Hall, Dr Robert Eckel, Professor Roy Taylor, and Dr Christos Mantzoros to explain what metabolic flexibility is, why your mitochondria sit at the centre of it, and what you can actually do about it. What We Cover Why lactate is a fuel and a signal, not a waste product, and our best non-invasive window into mitochondrial function Whether a calorie really is a calorie, and what the…