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TWiV 1357: Furin, Naturally with Paul Bieniasz
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Paul Bieniasz joins TWiV to discuss his lab's discovery that the coronavirus nuclease NSP15 cuts viral RNA into oligonucleotides that are reinserted elsewhere in the viral RNA, generating insertion mutations at a frequency above 10⁻³ per genome, including new furin cleavage sites at the spike S1/S2 junction. Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Guest: Paul Bieniasz Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Genetic innovation in coronaviruses driven by a viral nuclease (bioRxiv) Letters read on TWiV 1357 Timestamps by Jolene Ramsey. Thanks! Picks of the Week Kathy – Jurassic…