VCs Would Bet on Open-Source AI Over OpenAI and Anthropic | E2341

Sep 23, 2026 · 1h 27m

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On this episode

Jason CalacanisHost
DMDave McClureGuest
JCJeff ClavierGuest
JFJenny FieldingGuest

About this episode

This Week In Startups is made possible by: Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Odoo: https://odoo.com/twist Rippling: https://rippling.ai/twist Plaud: https://plaud.ai/twist Harmonic: https://harmonic.ai/twist Today’s show: Anthropic and OpenAI released cheaper models on the same day with Claude Opus 5.5 and GPT-6, and these VCs would still bet on open source. Jason brings on Dave McClure of Practical Venture Capital, Jeff Clavier of Uncork Capital, and Jenny Fielding of Everywhere Ventures to discuss the argument for open-weight models over the frontier labs. Learn why median seed valuations have more than tripled since 2017. Why does Dave say…