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This Week in Startups

This Week in Startups

What VCs Really Think About Personal AI Agents | E2347

Oct 8, 2026 · 1h 19m

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This Week In Startups is made possible by: Plaud: https://plaud.ai/twist Odoo: https://odoo.com/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Quo: https://www.quo.com/perks/twist Today’s show: A personal AI agent that’s still invite-only just hit a $10 billion valuation. Guest host Deedy Das of Menlo Ventures is joined by Kanu Gulati of Khosla Ventures, Chris Farmer of SignalFire, and Sheel Mohnot of Better Tomorrow Ventures to debate whether Instinct can beat Meta’s Muse, what they actually use their own agents for, and what breaks when everyone’s agent makes the same move. Plus we’re also talking about OpenAI’s math breakthroughs, the Factory vs.…