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This Week in Startups

This Week in Startups

Is AI the new cigarettes? Our VC panel digs into Anthropic’s S-1 | E2356

Oct 29, 2026 · 1h 12m

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This Week In Startups is made possible by: PayPal: https://paypal.com/business The Conservation Fund: https://www.conservationfund.org/ Hostinger: https://hostinger.com/twist Plaud: https://plaud.ai/twist Today’s show: Anthropic’s S-1 is here, and finally, we can start to develop a real understanding for the AI economy and whether the numbers add up. Anthropic shows an operating profit, a mostly non-cash $80.7 billion loss, and customers spending a shocking 9x what they were spending on intelligence just one year ago. Is this the greatest business in history? Is AI now as addictive to enterprises as cigarettes once were to impressionable teens? On this week’s VC Roundtable, Jason Calacanis…