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No Priors: Artificial Intelligence | Technology | Startups

No Priors: Artificial Intelligence | Technology | Startups

Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI

Mar 20, 2026 · 1h 7m

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What happens when AI agents can design experiments, collect data, and improve — without a human in the loop? Andrej Karpathy joins Sarah Guo on the state of models, the future of engineering and education, thinking about impact on jobs, and his project AutoResearch: where agents close the loop on a piece of AI research (experimentation, training, and optimization, autonomously). 00:00 Andrej Karpathy Introduction 02:55 What Capability Limits Remain? 06:15 What Mastery of Coding Agents Looks Like 11:16 Second Order Effects of Natural Language Coding 15:51 Why AutoResearch 22:45 Relevant Skills in the AI Era 28:25 Model Speciation 32:30 Building More Collaboration Surfaces for Humans and AI…