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Take Back Your Health®

Take Back Your Health®

57: The Brain’s Immune System: How Metabolism Shapes Cognitive Health with Dr. David Perlmutter

Sep 16, 2026 · 1h 7m

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About this episode

What if the brain’s future is shaped by more than genetics and age? In this episode of Take Back Your Health®, Dr. Amy Myers reconnects with neurologist and author Dr. David Perlmutter to discuss the brain’s immune system, metabolism, inflammation, and the lifestyle factors that may influence cognitive health. Dr. Perlmutter joins Dr. Amy to discuss his newest book, Brain Defenders, and the role of microglia, the brain’s immune cells. They explore immunometabolism, blood sugar, sleep, exercise, diet, perimenopausal hormone changes, APOE4, and why brain-health work may need to begin long before symptoms appear. What you’ll learn in this episode: How microglia can shift between supportive and…