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The Dan Buettner Podcast

The Dan Buettner Podcast

The Critical Decades: How Daily Habits in Midlife Can Actively Delay Cognitive Decline

Jul 16, 2026 · 1h 6m

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About this episode

Long before the first signs of forgetfulness or confusion appear, the cellular ""seeds of dementia"" may already be taking root in the brain. Leading neurologists warn that cognitive decline isn't a sudden onset of old age, but a slow process that can begin up to 30 years before a clinical diagnosis. In this episode of the podcast, Dan dives into the hard science of prevention with Drs. Dean and Ayesha Sherzai, exploring how a groundbreaking new blood test is helping doctors track early neurological damage long before symptoms show. We also break down the concept of genetic "penetrance"—revealing why carrying a dementia gene does not mean you are destined to get the disease, and how…