Dr. Tyler Panzner: Hidden Trade-Offs of Longevity Supplements and the Advantage of Topical Delivery

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Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and serotonin from the brain. For these individuals, common polyphenols marketed for inflammation and longevity, including curcumin, act as weak MAOA inhibitors that further slow neurotransmitter breakdown. The result is a quiet buildup of stimulation that gets misread as anxiety, insomnia, or unexplained agitation, with no obvious connection to the supplement bottle that caused it. In this episode of Biohacking Beauty, Dr. Tyler Panzner joins us to translate exactly this kind of pharmacological nuance into protocols people can actually use. He…